Clinical pathological analysis of synovial sarcoma

• DOI: 10.1007/s11805-007-0246-x
• Publication Date: 2007-09-26T08:26:18Z
• Authors: Ling Yang; Bogen Song; zhongjie Lin; Weiming Zhang; Qinhe Fan
• Keywords: Synovial Sarcoma

OBJECTIVE To investigate the clinical diagnosis and differential diagno -sis of synovial sarcoma (SS). METHODS A total of 41 paraffin-embedded synovial sarcoma samples were examined by H&E staining, immunohistochemistry staining and the re -verse transcriptase polymerase chain reaction (RT-PCR), in order to provide a scientific bases for diagnosis and differential diagnosis. RESULTS Twelve cases were a biphasic type, 22cases were a mono-phasic fibrous type, and 7 cases were a poorly differentiated type. Thirty-six cases were both CK (and/or EMA) and Vim positive. Five cases were only Vim positive. A SYT-SSX fusion gene was detected in 18 cases by RT-PCR. CONCLUSION By observation of the histomorphology, immunohisto -chemistry markers and detection of a SYT-SSX fusion gene, we can make a clinical pathological diagnosis of synovial sarcoma.