The epidemiology of transient synovitis in Liverpool, UK

• DOI: 10.1007/s11832-014-0556-5
• Publication Date: 2014-01-21T11:05:09Z
• Authors: William D. Harrison; A. K. Vooght; R. Singhal; C. E. Bruce; D. C. Perry
• Keywords: Etiology; Rate ratio

The epidemiology of transient synovitis is poorly understood, and the aetiology unknown, although a suggestion viral association predominates.This population-based study investigated in order to formulate aetiological theories pathogenesis.Cases Merseyside were identified between 2004 2009. Incidence rates determined analysed by age, sex, season region residence. Socioeconomic deprivation scores generated using Index Multiple Deprivation, allocated postcode. Poisson confidence intervals calculated regression was used check for trends.Two hundred fifty-nine cases over 5.5 years. annual incidence 25.1 (95 % CI 22.1-28.5) per 100,000 0-14 year-olds. Male female ratio 3.2:1 (p < 0.001). Mean age at presentation 5.4 years 5.0-5.8), which demonstrated near-normal distribution. No relationship seasonality = 0.64). A correlation with socioeconomic Merseyside: rate 1.16 1.06-1.26, p 0.001), further analysis within subregion Liverpool did not confirm this finding 0.35).The normal distribution disease suggests specific entity. absence casts some doubt on popular theory aetiology. consistent gradient both challenges previous an Perthes' disease. This paper provides ecological evidence that may challenge existing theories, though remains enigma.