Red Blood Cells Mean Corpuscular Volume (MCV) and Red Blood Distribution Width (RDW) Parameters as Potential Indicators of Regenerative Potential in Older Patients and Predictors of Acute Mortality – Preliminary Report

• DOI: 10.1007/s12015-020-09977-6
• Publication Date: 2020-05-05T20:03:31Z
• Authors: Katarzyna Brzeźni...; Joanna Rupa-Matysek; Andrzej Tukiendorf; Tomasz Janus; Mirosław Franków; Marcus Daniel Lancé; Lidia Gil
• Keywords: Adult; Erythrocyte Indices; Male; 0303 health sciences; Middle Aged; Prognosis; Models, Biological; Article; 3. Good health; 03 medical and health sciences; ROC Curve; Odds Ratio; Humans; Regeneration; Female; Mortality; Emergency Service, Hospital; Aged

Abstract This study presents the statistical results of patients who had been recently discharged from hospital within one month after their treatment in emergency department (ED). Using routine (14,881) MCV and RDW measurements tools, we could predict acute mortality these ( N = 1158), adjusted for age. It is likely that an increase parameters may correlate some our older with a poor prognosis increased level circulating IGF–I, which affects red blood cell parameters. The research prognostic statistics analyzed clinical factors as well speculates on potential correlation regenerative stem-cell compartment. Analysis shows both are statistically significant (Area Under Curve [AUC], lower CI 95% >50%) predictors ED patients. classification based threshold (= 92.2 units) indicates proper nearly 6 10 subjects (AUC >58%), whereas taking into account (=13.8%) no more than 7 individuals. report concludes by employing strongly fitting (95%) quadratic modeling ORs against biomarkers studied, can notice similar relationship between diagnostic tools to outcomes Although alone 10% higher value terms predicting early death were admitted subsequently hospitalized, also measurement improved accuracy 2.5% compared alone.