Blood glucose and epicardial adipose tissue at the hospital admission as possible predictors for COVID-19 severity

• DOI: 10.1007/s12020-021-02925-5
• Publication Date: 2021-11-03T03:02:43Z
• Authors: G. Guarisco; M. Fasolo; D. Capoccia; G. Morsello; A. Carraro; P. Zuccalà; R. Marocco; C. Del Borgo; G. Pelle; A. Iannarelli; E. Orlando; A. Spagnoli; I. Carbone; M. Lichtner; G. Iacobellis; F. Leonetti
• Keywords: Hounsfield scale

To study the possible association of CT-derived quantitative epicardial adipose tissue (EAT) and glycemia at admission, with severe outcomes in patients COVID-19. Two hundred twenty-nine consecutively hospitalized for COVID-19 from March 1st to June 30th 2020 were studied. Non contrast chest CT scans, confirm diagnosis pneumonia, performed. EAT volume (cm3) attenuation (Hounsfield units) measured using a post-processing software. The primary outcome was acute respiratory distress syndrome (ARDS) or in-hospital death. occurred 56.8% patients. Fasting blood glucose significantly higher group ARDS/death than better prognosis [114 (98–144) vs. 101 (91–118) mg/dl, p = 0.001]. vs without [103 (69.25; 129.75) 78.95 (50.7; 100.25) cm3, < 0.001] it positively correlated glycemia, PCR, fibrinogen, P/F ratio. In multivariable logistic regression analysis, age independently associated ARDS/death. Glycemia would appear be factors involved trend statistical significance. Our findings suggest that both EAT, easily measurable modifiable targets, could important predisposing Covid-19 complications.