Association between glycemic control and the outcome in hospitalized patients with COVID-19

• DOI: 10.1007/s12020-022-03078-9
• Publication Date: 2022-05-21T10:28:04Z
• Authors: Jamil Muqtadir Bh...; Syed Ali Raza; Muhammad Owais Sh...; Ayesha Akhtar; Tauseef Ahmed; Bhagwan Das
• Keywords: Blood Glucose; Glycated Hemoglobin; 03 medical and health sciences; 0302 clinical medicine; COVID-19; Humans; Original Article; Glycemic Control; Retrospective Studies; 3. Good health

Coronavirus disease 2019 (COVID-19) clinical outcome and disease severity affected by several factors; deterioration of glycemic control is one of them. Therefore, achieving optimum blood glucose parameters is hypothesized for better consequences of COVID-19. However, varying data supporting this hypothesis is available in literature. The intention of this study was to investigate the role of glycemic management on the prognosis of hospitalized COVID-19 patients with varying degrees of severity.From April 2020 to January 2021, we carried this retrospective cohort in a clinical care facility in Pakistan.Mortality was lowest in patients with HbA1c of less than 7% (53 mmol/mol) (p < 0.001). Similarly, mortality was found lowest in patients with fasting blood glucose less than 126 mg/dl and random blood glucose less than 160 mg/dl (p < 0.001 in each). In contrast, need for admission in critical care was found highest in patients with HbA1c between 7 and 10% (53-86 mmol/mol) (p 0.002). However, participants with blood glucose levels during fasting greater than 200 mg/dl and random blood glucose levels greater than 250 mg/dl were found to have a greater need for invasive mechanical ventilation. Cox regression hazard showed no difference in risk of death and invasive mechanical ventilation based on previous glycemic control.Effective diabetic management is correlated with a considerably lower risk of mortality and invasive mechanical ventilation in COVID-19 cases.