MiR-1273 g-3p Promotes Malignant Progression and has Prognostic Implications in Prostate Cancer

• DOI: 10.1007/s12033-021-00384-x
• Publication Date: 2021-08-24T17:07:14Z
• Authors: Yaxue Chang; Qian Deng; Zhenfeng Guan; Yongyi Cheng; Yi Sun
• Keywords: Male; Prostatic Neoplasms; Middle Aged; Prognosis; Up-Regulation; 3. Good health; Survival Rate; MicroRNAs; 03 medical and health sciences; 0302 clinical medicine; Cell Movement; Cell Line, Tumor; Lymphatic Metastasis; Biomarkers, Tumor; Humans; Aged; Cell Proliferation; Neoplasm Staging

Prostate cancer (PCa) is the most popular cancer of mankind. Our study aimed to provide the expression and the predictive significance of miR-1273 g-3p in PCa. Moreover, the effects on cell biological activities were also investigated. The relative expression of miR-1273 g-3p in PCa tissues and cell lines was validated by quantitative real-time PCR. Kaplan-Meier curve and Cox regression analyses were performed to indicate the prognostic value. The implications of miR-1273 g-3p on cell proliferation, migration, and invasion were validated using the CCK-8 and Transwell assay. Our results provided that the expression of miR-1273 g-3p was increased in PCa tissues and cell lines. The levels of miR-1273 g-3p were associated with Gleason score, TNM stage, clinical stage, and lymph node metastasis. Overexpression of miR-1273 g-3p indicated a promising overall survival rate. Cox regression results indicated miR-1273 g-3p might be an independent marker for PCa patients. Silenced miR-1273 g-3p inhibited PCa cell proliferation, migration, and invasion. In total, miR-1273 g-3p was increased in PCa and identified as a therapeutic target and a prognostic factor for PCa patients. Overexpression of miR-1273 g-3p might be an oncogene via accelerating cell proliferation, migration, and invasion.