Inflammation Promotes a Conversion of Astrocytes into Neural Progenitor Cells via NF-κB Activation

• DOI: 10.1007/s12035-015-9428-3
• Publication Date: 2015-09-17T07:53:43Z
• Authors: Sebastien Gabel; Eric Koncina; Gauthier Dorban; Tony Heurtaux; Cindy Birck; Enrico Glaab; Alessandro Michel...; Paul Heuschling; Luc Grandbarbe
• Keywords: Gliosis

Brain inflammation, a common feature in neurodegenerative diseases, is complex series of events, which can be detrimental and even lead to neuronal death. Nonetheless, several studies suggest that inflammatory signals are also positively influencing neural cell proliferation, survival, migration, differentiation. Recently, correlative suggested astrocytes able dedifferentiate upon injury may thereby re-acquire stem (NSC) potential. However, the mechanism underlying this dedifferentiation process remains unclear. Here, we report during early response reactive gliosis, inflammation induces conversion mature into progenitors. A TNF treatment decrease specific astrocyte markers, such as glial fibrillary acidic protein (GFAP) or genes related glycogen metabolism, while subset these cells re-expresses immaturity CD44, Musashi-1, Oct4. Thus, results appearance exhibit progenitor phenotype proliferate differentiate neurons and/or astrocytes. This maintained long present culture medium. In addition, highlight role for Oct4 process, since TNF-induced prevented by inhibiting expression. Our show activation NF-κB pathway through plays an important via re-expression These findings indicate first step gliosis fact resident mediated pathway.