SLAB51 Probiotic Formulation Activates SIRT1 Pathway Promoting Antioxidant and Neuroprotective Effects in an AD Mouse Model

• DOI: 10.1007/s12035-018-0973-4
• Publication Date: 2018-02-28T18:08:41Z
• Authors: Laura Bonfili; Valentina Cecarini; Massimiliano Cucc...; Mauro Angeletti; Sara Berardi; Silvia Scarpona; Giacomo Rossi; Anna Maria Eleuteri
• Keywords: Male; 0301 basic medicine; DNA Repair; Receptors, Retinoic Acid; Probiotics; Mice, Transgenic; DNA; Lipids; Article; Antioxidants; 3. Good health; Disease Models, Animal; 03 medical and health sciences; Neuroprotective Agents; Sirtuin 1; Alzheimer Disease; Animals; Tumor Suppressor Protein p53; Oxidation-Reduction; Signal Transduction

The gut-brain axis is a bidirectional communication network functionally linking the gut and central nervous system (CNS). Based on this, rational manipulation of intestinal microbiota represents novel attractive therapeutic strategy for treatment CNS-associated disorders. In this study, we explored properties probiotic formulation (namely SLAB51) in counteracting brain oxidative damages associated with Alzheimer's disease (AD). Specifically, transgenic AD mice (3xTg-AD) were treated SLAB51 effects protein oxidation, neuronal antioxidant defence repair systems monitored, particular focus role SIRT1-related pathways. We demonstrated that markedly reduced stress by activating SIRT1-dependent mechanisms, thus representing promising adjuvant treatment.