Impact of radiotherapy delay on survival in glioblastoma

• DOI: 10.1007/s12094-012-0916-x
• Publication Date: 2012-07-23T12:42:28Z
• Authors: Izaskun Valduvieco; Eugènia Verger; Jordi Bruna; Lluís Caral; Teresa Pujol; Teresa Ribalta; Teresa Boget; Laura Oleaga; Estela Pineda; Francesc Graus
• Keywords: Adult; Aged, 80 and over; Male; Time Factors; Adolescent; Brain Neoplasms; Middle Aged; Prognosis; Combined Modality Therapy; Survival Analysis; 3. Good health; Young Adult; 03 medical and health sciences; Treatment Outcome; 0302 clinical medicine; Humans; Female; Radiotherapy, Adjuvant; Glioblastoma; Aged; Retrospective Studies

Previous studies in glioblastoma have concluded that there is no decrease in survival with increasing time to initiation of RT up to 6 weeks after surgery. Unfortunately, the number of glioblastoma patients who start RT beyond 6 weeks is not small in some countries. The aim of our study was to evaluate the effect of RT delay beyond 6 weeks on survival of patients who have undergone completed resection of a glioblastoma.We reviewed 107 consecutive glioblastoma patients who had a complete surgical resection at our hospital. Clinical data, including delay in initiation of RT, were prospectively collected. The impact of single parameters on overall survival was determined by univariate and multivariate analyses.According to univariate analysis, variables that had a prognostic influence on survival were age (p = 0.036), KPS (p = 0.031), additional treatment with CHT (p < 0.0001), and initiation of RT before 42 days (p = 0.009). Multivariate analysis indicated that Karnofsky performance scale, additional treatment with chemotherapy, and initiation of RT before 6 weeks after surgery were favorable, independent prognostic factors of survival.Survival is significantly reduced in glioblastoma patients if RT is not initiated within the 6 weeks after complete resection of the tumor.