Intraoperative irradiation in breast cancer: preliminary results in 80 patients as partial breast irradiation or anticipated boost prior to hypo-fractionated whole breast irradiation

• DOI: 10.1007/s12094-021-02728-0
• Publication Date: 2021-11-18T13:02:48Z
• Authors: X. Li; J. Sanz; N. Argudo; M. Vernet-Tomas; N. Rodríguez; L. Torrent; E. Fernández-Velilla; O. Pera; Y. Huang; P. Nicolau; M. Jiménez; M. Segura; M. Algara
• Keywords: Breast Neoplasms; Mastectomy, Segmental; 3. Good health; 03 medical and health sciences; Breast cancer; Partial breast irradiation; 0302 clinical medicine; Intraoperative irradiation; Quality of Life; Hypofractionation; Humans; Female; Radiation Dose Hypofractionation; Radiotherapy, Adjuvant; Breast; Radiation Injuries; Patient reported outcomes; Boost; Research Article

To present the first results of intraoperative irradiation (IORT) in breast cancer with a low-energy photon system used as partial (PBI) or an anticipated boost before whole hypo-fractionated (IORT + WBI), concerning tolerance, side effects, quality life, and patient-reported outcomes. Eighty patients treated Intrabeam® 50 kV X-rays received 20 Gy dose intraoperatively were included. Moderate daily hypofractionation 2.7 15 fractions up to 40.5 was administered if high-risk factors present. Acute post-operative toxicity, surgery complications, chronic cosmesis Breast-Q questionnaire performed at follow-up visits. Thirty-one PBI remaining 49 IORT WBI. Only WBI group presented acute mainly mild dermatitis (11 patients) one subacute mastitis. A total fibrosis (18 grade I, 2 II), (30.5%) 3 (9.6%) PBI. The evaluation 73 resulted poor, fair, good excellent 2, 7, 38 26 patients, respectively. In scored higher, especially terms their psychosocial well-being (78 vs 65) satisfaction radiation-induced toxicity (77 72, respectively) compared group. is well-tolerated procedure low favorable outcomes when