Use of pyridoxine and pyridostigmine in children with vincristine-induced neuropathy

• DOI: 10.1007/s12098-010-0096-z
• Publication Date: 2010-06-07T19:13:45Z
• Authors: Sinan Akbayram; Cihangir Akgun; Murat Doğan; Refah Sayin; Huseyin Caksen; Ahmet Faik Oner
• Keywords: Male; Adolescent; Pyridoxine; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Antineoplastic Agents, Phytogenic; 3. Good health; Polyneuropathies; 03 medical and health sciences; Treatment Outcome; 0302 clinical medicine; Vincristine; Child, Preschool; Vitamin B Complex; Humans; Drug Therapy, Combination; Female; Cholinesterase Inhibitors; Child; Pyridostigmine Bromide

Four children with vincristine (VCR)-induced neuropathy are being reported. All cases were followed with the diagnosis of acute lymphoblastic leukemia. Two were boys aged between 2 and 13 year. Electromyographic examination consisted of sensoriomotor polyneuropathy with axonal involvement in three patients. In another patient, it consisted of motor axonal polyneuropathy. In all patients, pyridoxine and pyridostigmine were successfully used in the treatment of VCR-induced neuropathy. They recovered completely with this drug combination. Recovering period of symptoms was between 1-2 week.