The Role of Presepsin Obtained from Tracheal Aspirates in the Diagnosis of Early Onset Pneumonia in Intubated Newborns

• DOI: 10.1007/s12098-018-2676-2
• Publication Date: 2018-04-14T01:21:02Z
• Authors: Dragana Savić; Aleksandra Simović; Slavica Marković; Gordana Kostić; Biljana Vuletić; Snezana Radivojević; Marina Lišanin; Zoran Igrutinović; Radisa Pavlović
• Keywords: Male; Infant, Newborn; Lipopolysaccharide Receptors; Pneumonia, Ventilator-Associated; Peptide Fragments; Body Fluids; 3. Good health; Trachea; 03 medical and health sciences; Cross-Sectional Studies; Early Diagnosis; 0302 clinical medicine; Intubation, Intratracheal; Pneumonia, Bacterial; Humans; Female; Biomarkers

To investigate the role of presepsin obtained from tracheal aspirate of intubated newborns in the diagnosis of early neonatal pneumonia.A cross-sectional observational study was performed on 60 intubated newborns during the two-year period. Tracheal aspirate for examination was taken in aseptic conditions in usual toilets, by lavage with 2 ml of 0.9% NaCl in Mucus suction set. On the same day, presepsin (blood) was measured.There were 34 newborns in the examined group (with pneumonia) and 26 in the control group. Patient groups were similar regarding demographic characteristics related to gender and Apgar score. The coefficients of simple linear correlation revealed the statistically significant connection between presepsin (from tracheal aspirate) and birth body weight, presepsin (plasma), maternal infection and pneumonia. Significant differences in the values of presepsin (from tracheal aspirate) (p < 0.001) and birth body weight (p = 0.036) were found.In intubated newborns, measurements of presepsin obtained from tracheal aspirate suggested that it can be used as a complementary marker in diagnosing early onset neonatal pneumonia.