A Randomized Controlled Trial to Prevent Depression and Ameliorate Insulin Resistance in Adolescent Girls at Risk for Type 2 Diabetes

• DOI: 10.1007/s12160-016-9801-0
• Publication Date: 2016-06-23T11:42:05Z
• Authors: Lauren B. Shomaker; Nichole R. Kelly; Courtney K. Pickw...; Omni L. Cassidy; Rachel M. Radin; Lisa M. Shank; Anna Vannucci; Katherine A. Thom...; Sara A. Armaiz-Fl...; Sheila M. Brady; Andrew P. Demidowich; Ovidiu A. Galescu; Amber B. Courville; Cara Olsen; Kong Y. Chen; Eric Stice; Marian Tanofsky-K...; Jack A. Yanovski
• Keywords: Depression

Prospective data suggest depressive symptoms worsen insulin resistance and accelerate type 2 diabetes (T2D) onset.We sought to determine whether reducing in overweight/obese adolescents at risk for T2D would increase sensitivity mitigate risk.We conducted a parallel-group, randomized controlled trial comparing 6-week cognitive-behavioral (CB) depression prevention group with health education (HE) control 119 adolescent girls mild-to-moderate (Center Epidemiological Studies-Depression Scale [CES-D] ≥16) family history. Primary outcomes were baseline post-intervention changes CES-D whole body index (WBISI), derived from 2-h oral glucose tolerance tests. Outcome compared between groups using ANCOVA, adjusting respective outcome, puberty, race, facilitator, history degree, age, adiposity, adiposity change. Multiple imputation was used missing data.Depressive decreased (p < 0.001) CB HE posttreatment, but did not differ (ΔCESD = -12 vs. -11, 95 % CI difference -4 +1, p 0.31). Insulin stable > 0.29) (ΔWBISI 0.1 0.2, -0.6 +0.4, 0.63). Among all participants, reductions associated improvements 0.02).Girls displayed reduced following 6 weeks of or HE. Decreases related sensitivity. Longer-term follow-up is needed either program causes sustained decreases sensitivity.The registered clinicaltrials.gov (NCT01425905).