TLR2, TLR3, and TLR4 activation specifically alters the oxidative status of intestinal epithelial cells

• DOI: 10.1007/s12192-013-0461-8
• Publication Date: 2013-09-25T14:59:29Z
• Authors: Eva Latorre; Carmen Mendoza; Elena Layunta; Ana I. Alcalde; José E. Mesonero
• Keywords: TLR3; Intestinal mucosa; Intestinal epithelium

Intestinal inflammatory diseases are the result of multiple processes, including mucosal oxidative stress and perturbed homeostasis between commensal bacteria immunity. Toll-like receptors (TLRs) recognize molecular-associated microorganisms' patterns trigger innate immunity responses contributing to intestinal responses. However, TLRs effects on redox balance in mucosa remain unknown. Therefore, present study analyzes effect TLR2, TLR3, TLR4 both damage lipids proteins, activity antioxidant enzymes enterocyte-like Caco-2 cells. The results show that activation these increased lipid protein oxidation levels; however, is different depending TLR activated. These suggest might affect inflammation by not only their inherent responses, but also pro-oxidative epithelial