Serum levels of HSP70 and other DAMP proteins can aid in patient diagnosis after traumatic injury

• DOI: 10.1007/s12192-016-0694-4
• Publication Date: 2016-05-02T08:52:43Z
• Authors: Biqiong Ren; Guoying Zou; Yiran Huang; Guofeng Xu; Fei Xu; Junyu He; Haowen Zhu; Ping Yu
• Keywords: Procalcitonin; White blood cell

Danger-associated molecular patterns (DAMPs) are activated by endogenous signals that originate from stressed, injured, or necrotic cells, signifying "danger" to the host. In this study, we evaluated expression of DAMP heat shock protein 70 (HSP70) in trauma patients with and without secondary infections. Levels glucose (GLU), procalcitonin (PCT), total cholesterol (T-Chol), white blood cell (WBC) counts were also at three time stages after trauma. Our analysis showed levels serum HSP70 minor, moderate, severe injuries significantly higher than healthy each point post-injury (P < 0.01), injury group minor 1-6 h = 0.047). was correlated GLU negatively T-Chol period 0.008/0.032). WBC elevated trauma, mutual positive correlation 0.001). PCT increased later levels; these two periods, 24-48 60-90 0.008/0.041). continued rise infection, but dropped third infection. summary, our results suggest danger stress theory can be used predict severity