Vessel-selective, non-contrast enhanced, time-resolved MR angiography with vessel-selective arterial spin labeling technique (CINEMA–SELECT) in intracranial arteries

• DOI: 10.1007/s12194-013-0204-7
• Publication Date: 2013-03-09T05:57:45Z
• Authors: Masanobu Nakamura; Masami Yoneyama; Takashi Tabuchi; Atsushi Takemura; Makoto Obara; Satoshi Tatsuno; Seishi Sawano
• Keywords: Adult; Male; Cerebral Arteries; Healthy Volunteers; Cerebral Angiography; 03 medical and health sciences; Imaging, Three-Dimensional; 0302 clinical medicine; Cerebrovascular Circulation; Image Interpretation, Computer-Assisted; Feasibility Studies; Humans; Female; Spin Labels; Magnetic Resonance Angiography

We demonstrate the feasibility of the vessel-selective, non-contrast, time-resolved magnetic resonance angiography (MRA) technique, "contrast inherent inflow enhanced multi-phase angiography combining vessel-selective arterial spin labeling technique (CINEMA-SELECT)". This sequence consists of two major techniques: pulsed star labeling of arterial regions (PULSAR) and Look-Locker sampling. We hypothesize that this technique allows selective labeling of single intracranial arteries, consisting of high-resolution four-dimensional data with a wide coverage of the brain. In this study, a new vessel-selective, time-resolved angiographic technique is demonstrated that can produce individual angiograms non-invasively by labeling the principal arterial vessels proximal to the circle of Willis. Clear vessel delineation is achieved, and the separation of the three vessels is evident in healthy volunteers. This technique could play an important role in the assessment of the structure and hemodynamics of intracranial arteries without the use of contrast agents.