Effects of Humoral Immunity and Calreticulin Overexpression on Postoperative Course in Breast Cancer

• DOI: 10.1007/s12253-008-9112-2
• Publication Date: 2009-01-09T22:12:34Z
• Authors: Aleksandra Erić; Zorica Juranić; Zorka Milovanović; Ivan Marković; Momčilo Inić; Nevenka Stanojevi...; Vesna Vojinović-G...
• Keywords: 0301 basic medicine; Receptor, ErbB-2; Breast Neoplasms; Immunoglobulin A; 3. Good health; 03 medical and health sciences; Immunoglobulin M; Immunoglobulin G; Lymphatic Metastasis; Antibody Formation; Biomarkers, Tumor; Humans; Female; Calreticulin

The aim was to investigate whether the humoral immunity and overexpression of calreticulin in tumor tissue determined before surgery, correlate with incidence of metastases in breast cancer patients within two years after operation. Before operation, their humoral immunity and overexpression of caleticulin and Her-2/neu in tumor tissue were analyzed by immunohystochemistry. In 23 patients with metastases in regionally lymph nodes, seven had Her-2/neu overexpression. Among those seven patients, three developed distant metastasis (two women one year and in one woman two years after surgery) and all of them showed the presence of stromal IgG immunoreactivity and overexpression of calreticulin in their tumors tissue. Preliminary data showed that serum IgG immunoreactivity to tumor stroma in combination with overexpression of calreticulin in tumor cells correlate with postoperative appearance of metastases, particularly in the group of patients with Her-2/neu overexpressed tumors and metastases in axillary lymph nodes.