Oxidised Low-Density Lipoprotein and Its Receptor-Mediated Endothelial Dysfunction Are Associated with Coronary Artery Lesions in Kawasaki Disease

• DOI: 10.1007/s12265-019-09908-y
• Publication Date: 2019-08-19T20:03:23Z
• Authors: Yue-E He; Hui-Xian Qiu; Rong-Zhou Wu; Xing Rong; Hai-Tang Xu; Ru-Lian Xiang; Mao-Ping Chu
• Keywords: Male; Infant; Reproducibility of Results; Coronary Artery Disease; Mucocutaneous Lymph Node Syndrome; Scavenger Receptors, Class E; Lipoproteins, LDL; 03 medical and health sciences; 0302 clinical medicine; Predictive Value of Tests; Case-Control Studies; Child, Preschool; Humans; Female; Endothelium, Vascular; Prospective Studies; Child; Biomarkers

The study aimed to investigate the role of oxidised low-density lipoprotein (oxLDL)/lectin-like-oxLDL receptor-1 (LOX-1) in coronary artery lesions (CALs) in Kawasaki disease (KD) and of plasma oxLDL concentration in the early prediction of CALs in KD. This prospective study included 80 KD patients, 20 febrile and 20 healthy children. oxLDL, LOX-1 and other parameters were analysed in the acute phase. Plasma oxLDL concentration and LOX-1 mRNA expression in peripheral blood mononuclear cells (PBMCs) were significantly increased in KD patients compared with febrile and healthy children (P < 0.001 and P = 0.022, respectively), particularly in the group with CALs (P < 0.001 and P = 0.027, respectively). Coronary Z-score was significantly correlated with plasma oxLDL concentration and LOX-1 mRNA expression (r = 0.739 and 0.637, respectively; P < 0.01). The sensitivity and specificity of predicting CALs were 71.4% and 77.2%, respectively, at plasma oxLDL concentration ≥ 12.38 mU/L. oxLDL/LOX-1 may be involved in CAL development. The plasma oxLDL concentration in the acute phase is a potentially useful biological indicator for predicting CAL in KD patients.