Incidence of Acute Kidney Injury Is Lower in High-Risk Patients Undergoing Percutaneous Coronary Intervention Supported with Impella Compared to ECMO

• DOI: 10.1007/s12265-021-10141-9
• Publication Date: 2021-07-29T15:04:54Z
• Authors: Julian Schweitzer; Patrick Horn; Fabian Voss; Milena Kivel; Georg Wolff; Christian Jung; Tobias Zeus; Malte Kelm; Ralf Westenfeld
• Keywords: Incidence; Acute Kidney Injury; 3. Good health; 03 medical and health sciences; Extracorporeal Membrane Oxygenation; Percutaneous Coronary Intervention; 0302 clinical medicine; Acute Kidney Injury/epidemiology [MeSH] ; Humans [MeSH] ; Prospective Studies [MeSH] ; Incidence [MeSH] ; Retrospective Studies [MeSH] ; High-risk PCI ; Risk Factors [MeSH] ; Acute Kidney Injury/diagnosis [MeSH] ; Acute kidney injury ; Extracorporeal Membrane Oxygenation/adverse effects [MeSH] ; Percutaneous Coronary Intervention/adverse effects [MeSH] ; Original Article ; VA-ECMO ; Acute Kidney Injury/etiology [MeSH] ; Impella ; Mechanical circulatory support; Risk Factors; Humans; Original Article; Prospective Studies; Retrospective Studies

AbstractAcute kidney injury (AKI) is a common complication post-PCI. Here, in a single-center observational registry, we compared the frequency of AKI in patients at elevated risk for AKI (based on Mehran risk stratification scoring) who underwent VA-ECMO- or Impella-supported high-risk PCI. A total of 28 patients scheduled for elective high-risk PCI with mechanical circulatory support were studied prospectively. All patients were turned down for surgery due to exceedingly high risk. Allocation to VA-ECMO (n=11) or Impella (n=17) was performed according to site-specific restrictions on the daily availability of the VA-ECMO platform as a prospective enrollment and performed prior to initiation of PCI. We analyzed AKI incidence as our primary endpoint, as well as PCI success, duration, and peripheral complications. All patients were successfully revascularized and had MCS weaned at the end of the procedure. Baseline GFR and procedural contrast media were similar. Despite similar risks for AKI as calculated by the Mehran score (35 ± 18.9 vs. 31 ± 16.6 %; p=0.55), patients supported by Impella during PCI demonstrated a reduced incidence of AKI (55 vs. 12 %; p=0.03). MCS-assisted high-risk PCI with VA-ECMO or Impella is feasible. However, Impella is associated with a shorter procedure time and a lower incidence of AKI.