Woher stammen ungewöhnliche Seitenketten in Polyketiden?

• DOI: 10.1007/s12268-012-0259-8
• Publication Date: 2012-11-19T21:46:51Z
• Authors: Nick Quade; Dirk W. Heinz; Rolf Müller
• Keywords: 0303 health sciences; 03 medical and health sciences

Polyketides are medically relevant molecules that are assembled from precursor molecules in a stepwise fashion. The variability of introduced sidechains was considered to be limited due to the availability of cell metabolites. Recently, a newly discovered family of proteins, the crotonyl-CoA carboxylases/reductases (CCR), have been shown to generate new precursor molecules. This explains the observed chemical diversity of polyketides and paves the way for engineering of novel drugs.