A new dimeric neolignan from Magnolia grandiflora L. seeds

• DOI: 10.1007/s12272-014-0476-4
• Publication Date: 2014-09-05T02:35:00Z
• Authors: Hong-Mei Li; Su-Rong Zhao; Qiang Huo; Tao Ma; Hao Liu; Jae kyoung Lee; Young-Soo Hong; Cheng-Zhu Wu
• Keywords: 0301 basic medicine; Caspase 3; Cell Survival; Plant Extracts; Biphenyl Compounds; Molecular Conformation; Down-Regulation; Apoptosis; Antineoplastic Agents, Phytogenic; Lignans; 3. Good health; 03 medical and health sciences; Proto-Oncogene Proteins c-bcl-2; Magnolia; Cell Line, Tumor; Seeds; Humans; Drug Screening Assays, Antitumor; Cell Proliferation

Bioassay-guided fractionation of the MeOH extract of Magnolia grandiflora seeds resulted in the isolation of a new dimeric neolignan, named bishonokiol A (1), as well as two known neolignans magnolol (2) and honokiol (3). The structures of the compounds were determined on the basis of data obtained using NMR and MS. Bishonokiol A (1) showed potent anti-proliferative activities in four human cancer cell lines, with IC50 values ranging from 5.1 to 7.5 µM. Additionally, bishonokiol A (1) induced apoptosis, as well as down-regulated the expression of the anti-apoptotic protein Bcl-2 and caspase-3 cleavage in HepG2 cell line.