The Effect of taVNS on the Cerebello-Thalamo-Cortical Pathway: a TMS Study

• DOI: 10.1007/s12311-023-01595-5
• Publication Date: 2023-08-28T05:01:40Z
• Authors: Vesna M. van Midden; Zvezdan Pirtošek; Maja Kojović
• Keywords: Clinical neurology

Abstract fMRI studies show activation of cerebellum during transcutaneous auricular vagal nerve stimulation (taVNS); however, there is no evidence whether taVNS induced the translates to cerebellar closed loops involved in motor functions. We assessed propensity at 25 Hz (taVNS25) and 100 (taVNS100) modulate cerebello-thalamo-cortical pathways using transcranial magnetic stimulation. In our double blind within-subjects study thirty-two participants completed one visit which brain inhibition (CBI) was baseline (no stimulation) a randomized order taVNS100, taVNS25, sham (xVNS). Generalized linear mixed models with gamma distribution were built assess effect on CBI. The estimated marginal means trends each condition computed compared pairwise fashion Benjamini-Hochberg correction for multiple comparisons. CBI significantly increased taVNS100 taVNS25 xVNS ( p = 0.0003 0.0465, respectively). current intensity conditioning stimulus had significant has frequency dependent pathway. participates closed-loop circuits motor, cognitive, affective operations may serve as an entry modulating effects taVNS.