The Role of Cognitive Reserve in Protecting Cerebellar Volumes of Older Adults with mild Cognitive Impairment

• DOI: 10.1007/s12311-024-01695-w
• Publication Date: 2024-04-19T05:01:38Z
• Authors: Maria Devita; Giulia Debiasi; Mariagiulia Anglani; Chiara Ceolin; Ilaria Mazzonetto; Chiara Begliomini; Simone Cauzzo; Cecilia Raffaelli; Alessandro Lazzarin; Adele Ravelli; Alessandra Bordignon; Marina De Rui; Giuseppe Sergi; Alessandra Bertoldo; Daniela Mapelli; Alessandra Coin
• Keywords: Cerebellar vermis; Cognitive reserve; Montreal Cognitive Assessment

Abstract The present study aims to investigate the relationship between cerebellar volumes and cognitive reserve in individuals with Mild Cognitive Impairment (MCI). A description of proxies terms different across lobules is also provided. 36 MCI underwent neuropsychological (MoCA, MMSE, Clock test, CRIq) assessment neuroimaging acquisition magnetic resonance imaging at 3 T. Simple linear correlations were applied measures. Multiple regression models then used estimate standardized coefficients 95% confidence intervals. features highlighted a significant association CRIq_Working activity specific motor volumes: Left_V (ρ = 0.40, p 0.02), Right_V (r 0.42, 0.002), Vermis_VIIIb 0.47, 0.003), Left_X -0.46, 0.002) Vermis_X 0.35, 0.03). Furthermore, scores correlated certain implicated cognition: Left_Crus_II, Vermis VIIb, Left_IX. MMSE was associated only Right_VIIB volume while Drawing Test both Left_Crus_I Right_Crus_I -0.42 r 0.02, respectively). This suggests that higher lobule Working may play predominant role this association. These findings contribute understanding reserve, highlighting potential modulatory on cerebellum response decline. Graphical