The variable functional effects of the pacing site in normal and scarred ventricles

• DOI: 10.1007/s12350-009-9135-4
• Publication Date: 2009-09-03T17:09:07Z
• Authors: Luisa Muñoz del R...; Carol Stillson; Michael Lesh; Elias Botvinick
• Keywords: Radionuclide angiography

The pacing site has been shown to influence functional improvement with cardiac resynchronization therapy. We evaluated the effects of on left ventricular (LV) function in an animal model. Equilibrium radionuclide angiography was acquired sinus rhythm (NSR) and pacing, from three sites seven normal eight infarcted dogs. QRS duration, electrical activation pattern, wall motion, LV ejection fraction (EF), synchrony contraction, mean arterial pressure (MAP), were related infarct size, during each 120 episodes. Little changed normals. In dogs, worsened, LVEF MAP often fell. These changes altered patterns which influenced by but not size. Hemodynamic after infarction found vary associated conduction synchrony.