Acupuncture stimulation at GB34 suppresses 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced oxidative stress in the striatum of mice

• DOI: 10.1007/s12576-017-0547-7
• Publication Date: 2017-06-10T06:51:42Z
• Authors: Yukyung Lee; Gaeun Choi; Hyongjun Jeon; Dongsoo Kim; Sun Ryu; Sungtae Koo; Ki-Tae Ha; Seungtae Kim
• Keywords: MPTP; Nigrostriatal pathway

Recent studies have suggested that increased oxidative stress is a potential etiology in Parkinson’s disease (PD). In this study, we investigated whether acupuncture regulates antioxidants the striatum (ST) of PD mouse model. Male C57BL/6 mice were administered 30 mg/kg 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) intraperitoneally once day for 5 days and given stimulation at SI3 or GB34 (Yanglingquan) was 12 consecutive days. Dopaminergic neuronal survival nigrostriatal pathway DJ-1 expression ST evaluated by immunostaining, activities superoxide dismutase (SOD) catalase (CAT) enzyme-linked immunosorbent assay. MPTP administration induced dopaminergic death pathway, which suppressed GB34. also SOD CAT ST, restored These results indicate neuroprotective effect due to regulation antioxidants.