Possible involvement of central oxytocin in cisplatin-induced anorexia in rats

• DOI: 10.1007/s12576-017-0550-z
• Publication Date: 2017-06-14T17:18:33Z
• Authors: Koichi Arase; Hirofumi Hashimoto; Satomi Sonoda; Hiromichi Ueno; Reiko Saito; Yasuhito Motojima; Mitsuhiro Yoshimura; Takashi Maruyama; Keiji Hirata; Yasuhito Uezono; Yoichi Ueta
• Keywords: Anorexia; Area postrema; Supraoptic nucleus; Oxytocin receptor; Solitary tract

During cancer chemotherapy, drugs such as 5-HT3 receptor antagonists have typically been used to control vomiting and anorexia. We examined the effects of oxytocin (OXT), which has linked appetite, on cisplatin-induced anorexia in rats. Fos-like immunoreactivity (Fos-LI) expressed supraoptic nucleus (SON), paraventricular (PVN), area postrema solitary tract (NTS) after intraperitoneal (ip) administration cisplatin. also fluorescence intensity OXT-mRFP1 ip cisplatin transgenic The mRFP1 was significantly increased SON, PVN, NTS abolished by OXT antagonist (OXTR-A) pretreatment. In OXT-LI cells, Fos expression SON PVN suppressed OXTR-A These results suggested that central may be involved