Dietary nucleotides extend the life span in Sprague-Dawley rats

• DOI: 10.1007/s12603-012-0399-z
• Publication Date: 2012-10-22T05:16:18Z
• Authors: M. Xu; R. Liang; Q. Guo; S. Wang; M. Zhao; Z. Zhang; Junbo Wang; Yong Li
• Keywords: Life span; Senescence

To observe the effect of prolonged feeding dietary nucleotides (NTs), and to clarify NTs on life extension Sprague-Dawley rats. There were 50 rats in each group (male:female ratio=1:1), which fed diets supplemented with at concentrations 0%, 0.01%, 0.04%, 0.16% 0.64% (wt/wt) from age 4 weeks until natural death. We investigated moribundity mortality, survival time, spontaneous tumor incidence, serum oxidative status. have significantly influence body weight first 3 month old food consumption male throughout span; it did dose-dependently inhibit age-related decrease activities antioxidant enzymes increase levels lipid peroxidation product both sexes. notably increased mean span, maximal span. Compared control group, incidence death tumors was decreased groups Long-term could span rats, especially, tumor-bearing ones. Moreover, antioxidative property may be responsible for