Frailty and Quality of Life in Older Adults with Metabolic Syndrome — Findings from the Healthy Older People Everyday (HOPE) Study

• DOI: 10.1007/s12603-021-1609-3
• Publication Date: 2021-03-03T09:04:20Z
• Authors: M.Z. Chen; M.W.K. Wong; J.Y. Lim; Reshma Aziz Merchant
• Keywords: Depression; Demographics; Cross-sectional study

Metabolic syndrome (MetS) and frailty are both associated with increased morbidity mortality. Frailty is reduced quality of life (QoL) but association QoL MetS have produced mixed results suggesting that other factors such as disease burden, obesity depression may a more significant influence. We aim to investigate the demographics frail participants MetS, relationship between in MetS. Cross-sectional population study involving 292 older adults ≥ 65 years was defined using Modified ATP III for Asians which requires presence 3 or following 5 components 1) waist circumference 90cm males 80cm females, 2) TG 150mg/dL, 3) HDLc < 40mg/dL 50mg/dL 4) blood pressure 130/85mmHg use anti-hypertensive medication, 5) fasting plasma glucose 100mg/dL pharmacological treatment diabetes mellitus. Data were collected on demographics, (FRAIL), (Euroqol-5D), perceived health, functional status, cognition, Timed-Up-and-Go (TUG), hand-grip strength (HGS). 40.4% pre-frail (MetSprefrail) 7.2% (MetSfrail). MetSfrail significantly older, had lower education level, higher polypharmacy burden prevalence diabetes. The at least 1 activity daily living impairment 4 times higher, 9 than their robust counterparts. also longer TUG, poor grip health. After adjusting age, gender education, much odds EQ-5D moderate extreme problems mobility (Odds Ratio (OR) =10.99, CI 2.62–46.14), usual activities (OR=37.82, 3.77–379.04) pain (OR=10.79, 3.18–36.62). Index Value Perceived Health improved by 0.1 (Mean Difference (MD) =0.07, 0.04–0.10) 6.0 (MD=6.01, 3.29–8.73) respectively status improved. depression, polypharmacy, greater impairment, poorer screening personalized management crucial be mediator negative outcomes reversible.