Association between Preoperative hs-CRP/Albumin Ratio and Postoperative SIRS in Elderly Patients: A Retrospective Observational Cohort Study

• DOI: 10.1007/s12603-022-1761-4
• Publication Date: 2022-03-16T09:02:41Z
• Authors: C. Chen; X. Chen; J. Chen; J. Xing; Z. Hei; Q. Zhang; Z. Liu; Shaoli Zhou
• Keywords: Male; Prognosis; Systemic Inflammatory Response Syndrome; 3. Good health; 03 medical and health sciences; C-Reactive Protein; Postoperative Complications; 0302 clinical medicine; Albumins; Humans; Aged; Retrospective Studies

Systemic inflammatory response syndrome (SIRS) is one of the severe postoperative complications in elderly patients and seriously affects their prognosis survival rate. Heretofore, there have been no reliable accurate methods to predict SIRS patients. The aim this study was determine whether increased preoperative hs-CRP/albumin ratio (CAR) associated with population. data aged ≥ 65 years who underwent general anesthesia two centers Third Affiliated Hospital Sun Yat-sen University between January 2015 September 2020 were retrieved analyzed. Based on perioperative dataset, we used targeted maximum likelihood estimation (TMLE) estimate association CAR Patients' calculated divided into groups (< 0.278 0.278) according its normal range our hospital. Adjusted odd ratios (aORs) 95% confidence intervals (CIs) respectively. Further sensitivity analyses conducted evaluate robustness results. A total 16141 accessed 7009 them enrolled final analysis, 1674 (23.9%) developed within 3 days after surgery. Compared non-SIRS patients, had a significantly longer hospitalization, higher cost risk in-hospital mortality. < 0.278, found that for development multivariable adjustment [aOR = 1.27; CI (1.21, 1.33)]. interaction effect stronger among following characteristics: 75 years, male, comorbid diabetes mellitus admitted ICU surgery, duration surgery 120 minutes, cerebral or skin, spine joint (all P 0.001). above results remained robust analysis. Preoperative Special attention should be paid so as reduce incidence SIRS.