Antidepressant-like Effect of Tetrahydroisoquinoline Amines in the Animal Model of Depressive Disorder Induced by Repeated Administration of a Low Dose of Reserpine: Behavioral and Neurochemical Studies in the Rat

• DOI: 10.1007/s12640-013-9454-8
• Publication Date: 2014-01-09T14:56:36Z
• Authors: Lucyna Antkiewicz...; Agnieszka Wąsik; Edyta Możdżeń; Irena Romańska; Jerzy Michaluk
• Keywords: Neurochemical; Reserpine; Neurochemistry; Tetrahydroisoquinoline; Animal model

Animal models are widely used to study antidepressant-like effect in rodents. However, it should be mentioned that pharmacological do not always take into account the complexity of disease process. In present paper, we demonstrated repeated but acute treatment with a low dose reserpine (0.2 mg/kg i.p.) led model depression which was based on its inhibitory vesicular monoamine transporter 2, and monoamines depleting action brain. fact, observed chronic induced distinct depressive-like behavior forced swim test (FST), additionally, produced significant decrease level dopamine, noradrenaline, serotonin brain structures. 1,2,3,4-Tetrahydroisoquinoline (TIQ) close methyl derivative, 1-methyl-1,2,3,4-tetrahydroisoquinoline (1MeTIQ) exo/endogenous amines naturally mammalian FST rat. Both compounds, TIQ 1MeTIQ, administered chronically 25 (i.p.) together completely antagonized reserpine-produced as assessed by immobility time swimming time. Biochemical data were agreement behavioral experiments contrast administration structures impaired their metabolism. These neurochemical effects obtained after joint or 1MeTIQ (25 reserpine. A possible molecular mechanism responsible for antidepressant is discussed. On basis presented biochemical studies, suggest both compounds may effective therapy clinic new antidepressants which, when peripherally easily penetrate blood–brain barrier, endogenous have adverse side effects.