Lamotrigine Versus Pregabalin in the Management of Refractory Trigeminal Neuralgia: A Randomized Open Label Crossover Trial

• DOI: 10.1007/s12663-013-0513-8
• Publication Date: 2013-05-23T15:11:39Z
• Authors: Ankur Rustagi; Ajoy Roychoudhury; Ongkila Bhutia; Anjan Trikha; M. V. Padma Sriva...
• Keywords: 03 medical and health sciences; 0302 clinical medicine; 3. Good health

Carbamazepine (CBZ) formed the gold standard drug in trigeminal neuralgia (TN) treatment but faces high therapeutic failure. This defined the need to explore a second line of drug therapy. The study aimed at comparing two alternate drugs i.e. Lamotrigine (LTG) and Pregabalin (PGB), in the management of TN refractory to therapeutic doses of CBZ.Twenty-two patients with diagnosis of refractory TN were enrolled and randomly allotted into 2 groups of 11 each. Each group was subjected to a crossover analysis using LTG and PGB together with CBZ, for a period of 6 weeks. Patients maintained a pain diary, the scores of which, along with global evaluation scores, determined the primary outcome. Reevaluation of symptoms after 6 months was done to assess long term efficacy with study drugs.Both LTG and PGB were effective over CBZ alone (p < 0.05); however, statistically insignificant difference (p > 0.05) was observed between the two groups using Mann-Whitney tests. Unlike LTG, side effects like nausea, insomnia and concentration loss were minimal with PGB thus exhibiting greater patient compliance. Secondary analysis showed complete relief in 4 patients on PGB (mean dose 240.68 mg/day) while 6 had partial relief. Three patients on LTG (mean dose 310.90 mg/day) reported relapse of acute symptoms and required peripheral alcohol blocks.Pregabalin has potential anti-neuralgia properties comparable to LTG. However, the level of patient's tolerance seen with PGB exceeds that with LTG. 6 months follow-up records suggest that PGB together with CBZ offers a more reliable pain control than with LTG.