Matrix Metalloproteinase-9 (MMP-9) Expression in Different Subtypes of Ameloblastoma

• DOI: 10.1007/s12663-013-0538-z
• Publication Date: 2013-05-28T04:59:33Z
• Authors: Rachmitha Anne; Ening Krisnuhoni; Chusnul Chotimah; Benny Sjarief Latief
• Keywords: 03 medical and health sciences; 0302 clinical medicine

Ameloblastoma is a common benign odontogenic tumor of the jaw with a local invasive and highly destructive behavior and can develop in any age, with peak prevalence in 3rd-4th decade. Ameloblastoma can be divided into six histological types: follicular, plexiform, acanthomatous, desmoplastic, granular, and basal cell. Matrix metalloproteinase-9 (MMP-9) (92-kD gelatinase/type IV collagenases = gelatinase B) is involved in bone resorption by degradation of extracellular matrix and osteoclasts recruitment. Recent studies have found that MMP-9 is expressed by ameloblastoma and has a role in ameloblastoma local invasiveness.To analyze MMP-9 expression between different histological types of ameloblastoma.Forty samples of ameloblastoma were collected through consecutive sampling and the MMP-9 expression was detected using immunohistochemistry.All samples showed positive MMP-9 expression with moderate to strong intensity. 82.4 % plexiform type and 83.3 % mixed type have strong immunoexpression, significantly different with follicular type with only 36.4 % (P < 0.05).Ameloblastoma plexiform and mixed type have higher MMP-9 expression than ameloblastoma follicular type. Different MMP-9 expression may contribute in different ameloblastoma biological behavior.