Veillonella parvula promotes the proliferation of lung adenocarcinoma through the nucleotide oligomerization domain 2/cellular communication network factor 4/nuclear factor kappa B pathway

• DOI: 10.1007/s12672-023-00748-6
• Publication Date: 2023-07-14T20:30:50Z
• Authors: Wen Zeng; Yuhuan Wang; Zhe Wang; Mengge Yu; Kang Liu; Chengzhu Zhao; Yiyun Pan; Shudong Ma
• Keywords: Lung adenocarcinoma; 16 s rRNA sequencing; CCN4 expression; Research; Veillonella parvula; LLC cells; Neoplasms. Tumors. Oncology. Including cancer and carcinogens; RC254-282; 3. Good health

Enrichment of Veillonella parvula in the lung microbiota is strongly associated with non-small cell cancer (NSCLC) and induces progression adenocarcinoma vivo, but its actual role mechanism remain unexplored. This study analyzed correlation between NSCLC V. abundance based on 16 s rRNA sequencing results. The effects were observed vivo vitro using a C57 bl/6j mouse tumor-bearing model, bacterial co-culture combined transcriptome sequencing, TCGA database to explore validate growth promotion by molecular mechanism. revealed that was significantly enriched adenocarcinoma. In promoted mice suppressing infiltration tumor-associated T lymphocytes peripheral lymphocytes. It showed higher affinity for proliferation through adhesion or intracellular invasion. Further analysis differential gene expression KEGG enrichment induced CCN4 activated NOD-like receptor NF-κB signaling pathway cells. clarified activation via Nod2/CCN4 signaling, which proliferation. Thus, mediates Nod2/CCN4/NF-κB promote progression, thereby providing potential target diagnosing treating