Genetically predicted vitamins supplementation and risk of skin cancers: a Mendelian randomization study

• DOI: 10.1007/s12672-025-01905-9
• Publication Date: 2025-02-19T07:11:19Z
• Authors: Ping Qi; Liyun Chen; Aiwei Ma; Yiwen Zhang; Hai Lin; Wenqi Shi; Zijian Huang; Zixuan Tang; Wenshi Jiang; Mengjing Xu; Wancong Zhang; Shijie Tang
• Keywords: Mendelian Randomization; Linkage Disequilibrium; Genome-wide Association Study

The causal relationship between vitamins supplementation and the risk of skin cancers remains unclear. We conducted a Mendelian randomization study to assess associations in general population. aimed investigate (A-E) with using utilizing linkage disequilibrium score regression (LDSC) (MR). selected genome-wide significant single-nucleotide polymorphisms (SNPs) linked vitamin supplements (A-E). Summary-level data for melanoma, basal cell carcinoma, squamous carcinoma were obtained from large-scale association studies. applied inverse-variance weighted (IVW) method within random effects model, alongside median, MR-Egger, simple sensitivity analyses, MRlap methods ensure robustness. A meta-analysis was melanoma. STROBE-MR checklist followed throughout. Folate associated reduced melanoma (IVW OR = 0.88; 95% CI 0.80-0.96; P 0.006). MR analysis indicated inverse relationship. Heterogeneity analyses confirmed minimal impact individual SNPs. corrected potential estimation bias due sample overlap, which not significant, reinforcing IVW findings. ensured robust stable results. LDSC suggests weak folate Yet no found genetically predicted A, B6, B12, C, D, E, cancers. Both observational based on genetic variation provide evidence indicat that decreases suggesting interventions targeting may contribute primary prevention Further studies are needed explore other