PGAM1: a potential therapeutic target mediating Wnt/β-catenin signaling drives breast cancer progression

• DOI: 10.1007/s12672-025-01939-z
• Publication Date: 2025-02-11T19:38:05Z
• Authors: Yongxuan Wang; Wei Liu; Xudong Lai; Haixiong Miao; Xifeng Xiong
• Keywords: Breast cancer; PGAM1; Neoplasms. Tumors. Oncology. Including cancer and carcinogens; Cell migration; Cell proliferation; RC254-282; Wnt/β-catenin signaling

Phosphoglycerate mutase 1 (PGAM1) has been identified as a key player in the progression and metastasis of various human cancer types, including breast (BC); however, its precise oncogenic mechanism remains unclear. The present study aimed to investigate mechanisms PGAM1 establish potential therapeutic target. Comprehensive analyses from Tumor Immune Estimation Resource 2.0 Cancer Genome Atlas databases revealed significant upregulation BC, correlating with poor clinical outcomes. Additionally, elevated expression was confirmed BC samples. Silencing specific small hairpin RNA cells resulted marked reduction cell proliferation, invasiveness migration, alongside increased apoptosis cycle arrest. In vivo experiments using tumor-bearing nude mice demonstrated that knockdown significantly reduced tumor volume weight, effectively inhibiting growth. Mechanistic investigations suggested promoted tumorigenesis through activation Wnt/β-catenin signaling pathway, both vitro vivo. Therefore, enhances malignancy via highlighting promising target for treatment.