Chromosomal disorders: estimating baseline birth prevalence and pregnancy outcomes worldwide

• DOI: 10.1007/s12687-017-0336-2
• Publication Date: 2017-09-26T02:41:43Z
• Authors: Sowmiya Moorthie; Hannah Blencowe; Matthew W. Darlison; Stephen Gibbons; Joy E. Lawn; Pierpaolo Mastroi...; Joan K. Morris; Bernadette Modell
• Keywords: Baseline (sea); Prevalence

Chromosomal disorders, of which Down syndrome is the most common, can cause multi-domain disability. In addition, compared to general population, there a higher frequency death before age five. many settings, large gaps in data availability have hampered policy-making, programme priorities and resource allocation for these important conditions. We developed methods, overcome this lack allow estimation burden affected pregnancies their outcomes different settings worldwide. For example, methods include simple equation relating percentage mothers 35 over birth prevalence. The results obtained provide starting point consideration services that be implemented care prevention disorders.