The Toxicology Investigators Consortium 2023 Annual Report

• DOI: 10.1007/s13181-024-01033-w
• Publication Date: 2024-09-10T18:02:13Z
• Authors: Adrienne Hughes; Alexandra Amaducci; Sharan L. Campleman; Shao Li; Mari Costantini; Meghan B. Spyres; Hannah Spungen; Jessica Kent; Alyssa Falise; Rachel Culbreth; Paul M. Wax; Jeffery Brent; Kim Aldy; ; Michael Abesamis; Peter Akpunonu; Timothy Albertson; Adam Algren; Afra Alsuwaidi; John Archer; Yaqdhan Al Atbil; Sukhshant Atti; Robert Avera; Kavita Babu; Alexander Baer; Fatma Al Balushi; Kevin Baumgartner; Gillian Beauchamp; Vik Bebarta; Melisa Lai Becker; Noah Berland; David Betting; Michael Beuhler; Steven Bird; Anna Bloom; Mathew Blundell; Evan Bradley; Nicklaus Brandehoff; Daniel Brooks; Jennie Buchanan; Michele Burns; Diane Calello; Vincent Calleo; Michel Camarena; Joshua Canning; Dazhe Cao; Joseph Carpenter; Stephanie Carreiro; Emma Cassidy; Rachel Castelli; Trevor Cerbini; Edward Cetaruk; Nathan Charlton; Michael Chary; Richard Chen; James Chenoweth; Samy Chettat; Michael Christian; Richard Church; Joseph Clemons; Daniel Colby; Ryan Cole; Albert Conicella; Matthew Cook; Matthew Correia; Christopher Counts; Colleen Cowdery; Robert Cox; Amelia Curtis; Paul Dargan; John Delbianco; Jason Devgun; Frank Dicker; Christopher Dion; Bernard Eisenga; Jason Elzinga; Claire Lindsey Ep...; Henry Farrar; Chris Feng; Derek Fikse; Ari Filip; Allison Font; Jonathan Ford; Carolyn Fox; Keith French; Aaron Frey; Kira Galeano; Hayley Gartner; Timlin Glaser; David Goldberger; Will Goodrich; Kimberlie Graeme; Powell Graham; Spencer Greene; Howard Greller; Matthew Griswold; Veronica Groff; Mayank Gupta; Stacey Hail; Thao-Phuong Chris...; Laurie Halmo; Alexandra Hamelin; Riley Hartmann; Benjamin Hatten; Marissa Hauptman; Kennon Heard; Will Heise; Robert Hendrickson; Reynaldo Hernandez; Michelle Hieger; Jacqueline Hiob; Ruby Hoang; Michael Hodgman; Christopher Holstege; Jason Hoppe; Keahi Horowitz; Zane Horowitz; Christopher Hoyte; Laura Hunter; Katherine Hurlbut; Janetta Iwanicki; Sundip Jagpal; Laura James; Lilyanne Jewett; Brett Johnson; David Johnson; Chase Jones; Seth Jones; Bryan Judge; Min Kang; Louise Kao; Sabrina Kaplan; Kenneth Katz; Ziad Kazzi; Mike Keenan; Abigail Kerns; Michael Khoury; Emily Kiernan; Ronald Kirschner; Kurt Kleinschmidt; Natalie Ebeling K...; Andrew Koons; Michael Kosnett; Michael Kowalski; James Krueger; Jessica Krueger; Shana Kusin; Jeffrey Lai; Dayne Laskey; Rebecca Latch; Ophir Lavon; Eric Lavonas; Alex Lazar; Jacob Lebin; Michael Levine; Brian Lewis; Erica Liebelt; Rafael Lima; David Liss; Annette Lopez; Scott Lucyk; Forrest Mahony; Greg Makar; Kevan Mamdouhi; Michael Marlin; Stacy Marshall; Kelsey Martin; Danae Massengill; Nik Matsler; Connor McDonald; Charles McElyea; Eric McGillis; Christopher Meaden; Avery Michienzi; Christopher Mitchell; Nadia Mohammad; Andrew Monte; Elizabeth Catheri...; Pamela Moore; Brent Morgan; Michael Mullins; Karen Muschler; Agnesa Mustafa; Kristine Nanagas; Lewis Nelson; Natalie Neumann; Kim-Long Nguyen; Tuyet-anh Nguyen; Matthew Noble; Supa Niruntarai; Ayrn O’Connor; Katherine O’Donnell; Devin Odom; Simon Ostrowski; Rittirak Othong; Jenna Otter; Daniel Overbeek; Serah Oyewole; Mehruba Parris; Lesley Pepin; Todd Phillips; Timothy Pollak; Shelby Randall; Rama Rao; Shanaz Rashid; Tony Rianprakaisang; Marc Rigatti; Morgan Riggan; Bradley Riley; Daniel Rivera; Brett Roth; Anne-Michelle Ruha; William Rushton; Nicholas Sajko; Steven Salhanick; Cynthia Santos; Nishita Saraiya; David Schaffer; Pieter Scheerlinck; Scott Schmalzried; Evan Schwarz; Michael Semple; Kerollos Shaker; Elizabeth Shanahan; Kapil Sharma; Sophia Sheikh; Eddie Shin; Reeves Simmons; Mark Simon; Michael Simpson; Serge Emile Simpson; Miya Smith; Jerry Snow; Arjumand Sohaila; Dawn Sollee; Tony Spadaro; Jennifer Stephani; Fermin Suarez; Suad Al Sulaimahi; Lachie Sund; Ryan Surmaitis; Courtney Temple; John Thompson; Stephen Thornton; Christopher Threa...; Michael Toce; Andrew Troger; David Vearrier; Steven Walsh; Sam Wang; George Warpinski; Mitchell Waters; Mary Wermuth; Jim Whitledge; Tyler Willing; Brian Wolk; David Wood; Mark Yarema; Tim Yeung; Luke Yip; Amy Young; Jennifer Zacharia; Matthew Zuckerman
• Keywords: Male; Adult; Aged, 80 and over; Adolescent; Poisoning; Antidotes; Infant; Middle Aged; Toxicology; United States; Young Adult; Child, Preschool; Humans; Female; Registries; Child; Aged

Since 2010, the American College of Medical Toxicology (ACMT) Toxicology Investigators Consortium (ToxIC) has maintained the ToxIC Core Registry, a national case registry of in-hospital and clinic patient consultations submitted by medical toxicology physicians. Deidentified patient data entered into the registry includes patient demographics, reason for medical toxicology evaluation, exposure agents, clinical signs and symptoms, treatments and antidotes administered, and mortality. This fourteenth annual report provides data from 7392 patients entered into the Core Registry in 2023 by 36 participating sites comprising 61 distinct healthcare facilities, bringing the total case count to 102331 between 2010 and 2023. Ethanol was the most commonly reported exposure agent class (24.4%), followed by opioids (22.7%), non-opioid analgesics (16.7%), and antidepressants (11.7%). For the first time since the registry's initiation, in 2023, ethanol was the leading agent of exposure. There were 98 fatalities (case fatality rate of 1.3%). Additional descriptive analyses in this annual report were conducted to describe the reasons for medical toxicology consultation by age in 2023, and yearly trends for opioid and psychoactive exposures, physostigmine and rivastigmine treatments, and acetaminophen exposures treated with fomepizole.