Anti-cancer potential of flavonoids: recent trends and future perspectives

• DOI: 10.1007/s13205-013-0117-5
• Publication Date: 2013-02-11T03:51:31Z
• Authors: Priya Batra; Anil K. Sharma
• Keywords: Betulinic acid; Topotecan; Chemoprotective

Cancer is a major public health concern in both developed and developing countries. Several plant-derived anti-cancer agents including taxol, vinblastine, vincristine, the campothecin derivatives, topotecan, irinotecan etoposide are clinical use all over world. Other promising include flavopiridol, roscovitine, combretastatin A-4, betulinic acid silvestrol. From this list one can well imagine predominance of polyphenols, flavonoids their synthetic analogs treatment ovarian, breast, cervical, pancreatic prostate cancer. Flavonoids present human diet comprise many polyphenolic secondary metabolites with broad-spectrum pharmacological activities potential role as agents. A positive correlation between flavonoids-rich (from vegetables fruits) lower risk colon, breast cancers lead to question that whether mediate protective effects chemopreventive or interact different genes proteins play chemotherapy. The current review emphasizes onto therapeutic by providing new insights into factors, regulation molecular mechanisms along significant protein interactions.