Long non-coding RNA LncKdm2b regulates cortical neuronal differentiation by cis-activating Kdm2b

• DOI: 10.1007/s13238-019-0650-z
• Publication Date: 2019-07-17T22:02:21Z
• Authors: Wei Li; Wenchen Shen; Bo Zhang; Kuan Tian; Yamu Li; Lili Mu; Zhiyuan Luo; Xiaoling Zhong; Xudong Wu; Ying Liu; Yan Zhou
• Keywords: Developmental Biology; Human genetics

The mechanisms underlying spatial and temporal control of cortical neurogenesis the brain are largely elusive. Long non-coding RNAs (lncRNAs) have emerged as essential cell fate regulators. Here we found LncKdm2b (also known Kancr), a lncRNA divergently transcribed from bidirectional promoter Kdm2b, is transiently expressed during early differentiation projection neurons. Interestingly, Kdm2b's transcription positively regulated in cis by LncKdm2b, which has intrinsic-activating function facilitates permissive chromatin environment at associating with hnRNPAB. Lineage tracing experiments phenotypic analyses indicated Kdm2b crucial proper migration These observations unveiled lncRNA-dependent machinery regulating neuronal differentiation.