Real-World Variability in the Prediction of Intracranial Aneurysm Wall Shear Stress: The 2015 International Aneurysm CFD Challenge

• DOI: 10.1007/s13239-018-00374-2
• Publication Date: 2018-09-10T11:39:41Z
• Authors: Kristian Valen-Se...; Aslak W. Bergersen; Yuji Shimogonya; Leonid Goubergrits; Jan Bruening; Jordi Pallares; Salvatore Cito; Senol Piskin; Kerem Pekkan; Arjan J. Geers; Ignacio Larrabide; Saikiran Rapaka; Viorel Mihalef; Wenyu Fu; Aike Qiao; Kartik Jain; Sabine Roller; Kent-Andre Mardal; Ramji Kamakoti; Thomas Spirka; Neil Ashton; Alistair Revell; Nicolas Aristokleous; J. Graeme Houston; Masanori Tsuji; Fujimaro Ishida; Prahlad G. Menon; Leonard D. Browne; Stephen Broderick; Masaaki Shojima; Satoshi Koizumi; Michael Barbour; Alberto Aliseda; Hernán G. Morales; Thierry Lefèvre; Simona Hodis; Yahia M. Al-Smadi; Justin S. Tran; Alison L. Marsden; Sreeja Vaippummadhom; G. Albert Einstein; Alistair G. Brown; Kristian Debus; Kuniyasu Niizuma; Sherif Rashad; Shin-ichiro Sugiyama; M. Owais Khan; Adam R. Updegrove; Shawn C. Shadden; Bart M. W. Cornel...; Charles B. L. M. ...; Philipp Berg; Sylvia Saalfield; Kenichi Kono; David A. Steinman
• Keywords: Patient-Specific Modeling; Middle Cerebral Artery; Artificial intelligence; /dk/atira/pure/subjectarea/asjc/2200/2204; Wall Shear Stress; Rotational angiography; FOS: Mechanical engineering; Computational fluid dynamics; Oceanography; Wall shear stress; Segmentation; Engineering; 0302 clinical medicine; https://purl.org/becyt/ford/1.2; UNCERTAINTY QUANTIFICATION; Uncertainty quantification; Physics; Models, Cardiovascular; Angiography; Geology; Prognosis; Mechanical engineering; Programming language; 3. Good health; Aerospace engineering; Neurology; Solver; Cerebrovascular Circulation; Radiographic Image Interpretation, Computer-Assisted; Medicine; PATIENT-SPECIFIC MODELLING; Radiology; Blood Flow Velocity; name=Cardiology and Cardiovascular Medicine; Pulmonary and Respiratory Medicine; Patient-specific modelling; 610; /dk/atira/pure/subjectarea/asjc/2700/2705; RUPTURE RISK; Mechanics; Article; Pathophysiology and Management of Cerebral Aneurysms; 03 medical and health sciences; Imaging, Three-Dimensional; Rupture risk; Predictive Value of Tests; WALL SHEAR STRESS; 616; Health Sciences; Aneurysm Screening; Humans; INTRACRANIAL ANEURYSM; Inflow; https://purl.org/becyt/ford/1; name=Biomedical Engineering; Shear stress; Hemodynamics; Reproducibility of Results; Intracranial Aneurysm; FOS: Earth and related environmental sciences; Intracranial aneurysm; Diagnosis and Treatment of Carotid Artery Disease; Aneurysm; Computer science; Management and Pathophysiology of Abdominal Aortic Aneurysms; Intracranial Aneurysms; Cerebral Angiography; Regional Blood Flow; Pipeline (software); Stress, Mechanical

Image-based computational fluid dynamics (CFD) is widely used to predict intracranial aneurysm wall shear stress (WSS), particularly with the goal of improving rupture risk assessment. Nevertheless, concern has been expressed over variability predicted WSS and inconsistent associations rupture. Previous challenges, studies from individual groups, have focused on aspects image-based CFD pipeline. The aim this Challenge was quantify total whole 3D rotational angiography image volumes five middle cerebral artery aneurysms were provided participants, who free choose their segmentation methods, boundary conditions, solver settings. Participants asked fill out a questionnaire about solution strategies experience CFD, provide surface distributions magnitude, which we objectively derived variety hemodynamic parameters. A 28 datasets submitted, 26 teams varying levels self-assessed experience. Wide segmentations, model extents, inflow rates resulted in interquartile ranges sac average up 56%, reduced < 30% after normalizing by parent WSS. Sac-maximum low area more variable, while rank-ordering cases or high showed only modest consensus among teams. Experience not significant predictor variability. exists prediction While techniques may be difficult standardize across our findings suggest that some could establishing guidelines for rates, blood properties, encouraging reporting normalized