An Accelerated Thrombosis Model for Computational Fluid Dynamics Simulations in Rotary Blood Pumps

• DOI: 10.1007/s13239-021-00606-y
• Publication Date: 2022-01-14T17:10:57Z
• Authors: Christopher Blum; Sascha Groß-Hardt; Ulrich Steinseifer; Michael Neidlin
• Keywords: Dynamics

Abstract Purpose Thrombosis ranks among the major complications in blood-carrying medical devices and a better understanding to influence design related contribution thrombosis is desirable. Over past years many computational models of have been developed. However, numerically cheap able predict localized thrombus risk complex geometries are still lacking. The aim study was develop test computationally efficient model for prediction rotary blood pumps. Methods We used two-stage approach calculate risk. first stage involves computation velocity pressure fields by fluid dynamic simulations. At second stage, platelet activation mechanical chemical stimuli determined through species transport with an Eulerian approach. compared existing clinical data on deposition within HeartMate II. Furthermore, operating point parameter sensitivity analysis performed. Results Our shows good correlation ( R 2 > 0.93) identifies bearing outlet stator region II as location most prone formation. calculation requires additional 10–20 core hours time. Conclusion concentration activated platelets can be surrogate low-cost marker determine potential regions pump. Relative comparisons possible even considering intrinsic uncertainty parameters conditions.