Pediatric Cardiovascular Multiscale Modeling using a Functional Mock-up Interface

• DOI: 10.1007/s13239-024-00767-6
• Publication Date: 2025-01-06T17:36:31Z
• Authors: Ellen E. Garven; Ethan Kung; Randy M. Stevens; Amy L. Throckmorton
• Keywords: Interface (matter)

Computational models of the cardiovascular system continue to increase in complexity. As more elements physiology are captured multiscale models, there is a need efficiently integrate subsystems. The objective this study demonstrate effectiveness coupling methodology, called functional mock-up interface (FMI), as applied modeling. model composed two subsystems: computational fluid dynamics (CFD) coupled lumped parameter (LPM). LPM packaged using FMI standard and imported into CFD subsystem an co-simulation architecture. functionality was demonstrated univentricular parallel circulation by means compatible tools, including ANSYS CFX Python. Predicted pressures flows were evaluated comparison with clinical data previously developed model. exchanged pressure flow between their boundaries at each timestep, demonstrating sufficient inter-subsystem communication. recreated from measurements patient-specific published. integrated effective approach for interfacing presented circulatory offers modular towards tool integration advantageous strategy modeling complex systems.