Prognostic impact of ERβ and MMP7 expression on overall survival in colon cancer

• DOI: 10.1007/s13277-010-0082-0
• Publication Date: 2010-08-02T13:19:57Z
• Authors: Yu-Jing Fang; Zhen-Hai Lu; Fang Wang; Xiao-Jun Wu; Li-Ren Li; Li-Yi Zhang; Zhi-Zhong Pan; De-Sen Wan
• Keywords: Adult; Male; Adenocarcinoma; Middle Aged; Prognosis; 3. Good health; Survival Rate; 03 medical and health sciences; 0302 clinical medicine; Risk Factors; Matrix Metalloproteinase 7; Colonic Neoplasms; Biomarkers, Tumor; Estrogen Receptor beta; Humans; Female; Aged; Neoplasm Staging; Retrospective Studies; Signal Transduction

Estrogen receptor beta (ERβ) is the most highly expressed protein in patients with colon cancer. Matrix metalloproteinase 7 (MMP7) consistently throughout cancer progression. We have previously shown that endocrine therapy can inhibit MMP7 expression cells. In this study, we aim to identify prognostic effects and correlation of ERβ context levels were assessed by immunohistochemistry normal mucosa tumoral tissues from 423 stage I-III The Cox proportional hazards regression model was applied analyze lifetime data, including overall survival (OS) cause-specific (CSS). 5-year rate significantly higher high nuclear than low (84.3% vs. 63.9%, respectively, p < 0.05). High related decreased OS (72% 90%, = 0.008) (86.6% 88.8%, 0.005) compared MMP7. subset ERβ, CSS among ERβ. conclusion, our results suggest a risk factor cancer, an independent ERβ-positive