Increased expression of Rab25 in breast cancer correlates with lymphatic metastasis

• DOI: 10.1007/s13277-012-0412-5
• Publication Date: 2012-05-29T04:13:51Z
• Authors: Y. X. Yin; F. Shen; H. Pei; Y. Ding; Hua Zhao; Min Zhao; Q. Chen
• Keywords: Progesterone receptor

Breast cancer is the most common in women worldwide. Studies have suggested that Ras-related protein 25 (Rab25), a member of Rab small GTPase family, involved pathogenesis breast cancer. In this study, we investigated whether expression Rab25 correlated with lymphatic metastasis and was positively oestrogen receptor (ER) progesterone (PR) tissues from 42 invasive ductal patients or without were collected levels mRNA measured by quantitative real-time PCR immunohistochemistry, respectively. The level significantly increased compared to metastasis. Immunohistochemical analysis demonstrated vascular endothelial growth factor (VEGF) highly expressed regardless ER PR positive negative. Higher VEGF expression. However, expressions PR-positive cancers much higher than PR-negative occurred. These data suggest associated metastasis, specifically better understanding mechanism may provide basis for development novel therapeutic target