High expression of FOXC1 is associated with poor clinical outcome in non-small cell lung cancer patients

• DOI: 10.1007/s13277-012-0629-3
• Publication Date: 2012-12-21T03:39:55Z
• Authors: Long-Xiao Wei; Run-Suo Zhou; Hai-Feng Xu; Jun-Yan Wang; Meng-Hui Yuan
• Keywords: Adult; Aged, 80 and over; Male; 0303 health sciences; Lung Neoplasms; Blotting, Western; Forkhead Transcription Factors; Adenocarcinoma; Middle Aged; Prognosis; 3. Good health; Immunoenzyme Techniques; 03 medical and health sciences; Carcinoma, Non-Small-Cell Lung; Lymphatic Metastasis; Biomarkers, Tumor; Carcinoma, Squamous Cell; Humans; Female; Lung; Aged; Follow-Up Studies; Neoplasm Staging

The aim of this study was to detect FOXC1 expression in human non-small cell lung cancer (NSCLC) and analyze its association with prognosis NSCLC patients. Expressional levels mRNA protein 30 cases corresponding non-tumor tissue samples were examined by quantitative real-time PCR Western blotting. Immunohistochemistry performed the 125 tissues. We found that tissues significantly higher than those High-level correlated poor tumor differentiation, tumor-node-metastasis stage, lymph node metastasis. Patients high showed lower overall survival rate low levels. Multivariate analysis an independent prognostic factor for Our suggests over-expression may play important role progression NSCLC, offer a valuable marker predicting outcome patients NSCLC.