WWTR1 promotes cell proliferation and inhibits apoptosis through cyclin A and CTGF regulation in non-small cell lung cancer

• DOI: 10.1007/s13277-013-1064-9
• Publication Date: 2013-08-19T05:05:51Z
• Authors: Li Wang; Zhenhong Chen; Yajuan Wang; De Chang; Longxiang Su; Yinghua Guo; Changting Liu
• Keywords: Hippo signaling pathway; XIAP

The Hippo pathway plays a major role in development and organ size control, its dysregulation contributes to tumorigenesis. WWTR1 is transcription coactivator acting downstream of the pathway. Recently, has been reported be overexpressed several human cancers including lung cancer. However, molecular mechanism regulating cancer aggressiveness remains ambiguous. In present study, we analyzed expression NSCLC cell lines found that was at both mRNA protein levels. Knockdown by siRNA interference A549 cells significantly inhibited proliferation increased paclitaxel-induced apoptosis. On other side, overexpression HBE line promoted addition, decreased after treatment due cycle arrest. Further analysis showed could induce cyclin A, connective tissue growth factor (CTGF) expression, inhibit caspase3 cleavage. conclusion, promotes malignant inhibits apoptosis A CTGF regulation.