Significance and prognostic value of Gli-1 and Snail/E-cadherin expression in progressive gastric cancer

• DOI: 10.1007/s13277-013-1185-1
• Publication Date: 2013-09-30T03:12:12Z
• Authors: Zhan-shan Wang; Yang Shen; Xu Li; Chong-zhi Zhou; Yu-gang Wen; Yu-biao Jin; Ji-kun Li
• Keywords: Adult; Male; Epithelial-Mesenchymal Transition; Middle Aged; Cadherins; Prognosis; Zinc Finger Protein GLI1; 3. Good health; Gene Expression Regulation, Neoplastic; 03 medical and health sciences; 0302 clinical medicine; Stomach Neoplasms; Cell Line, Tumor; Lymphatic Metastasis; Humans; Vimentin; Female; Hedgehog Proteins; Snail Family Transcription Factors; Aged; Neoplasm Staging; Transcription Factors

Abnormal activation of the hedgehog (Hh) signaling pathway has been found to be involved in occurrence, invasion, and metastasis cancers. Epithelial-mesenchymal transition (EMT) also plays an important role invasion However, significance Hh EMT gastric cancer is still unclear. This study aimed investigate prognostic value progressive cancer. Immunohistochemistry was performed detect expression Hh-induced transcriptional factor Gli-1 EMT-related molecules Snail E-cadherin 121 patients with Histological type, depth lymph node metastasis, pTNM stage were recorded. In cancer, increased markedly, closely associated decreased expression. Diffuse type abnormal independent factors influencing prognosis These findings suggest that related presence diffuse