Low level of high-density lipoprotein cholesterol correlates with poor prognosis in extranodal natural killer/T cell lymphoma

• DOI: 10.1007/s13277-013-1284-z
• Publication Date: 2013-10-12T06:10:44Z
• Authors: Liang Wang; Pei-dong Chi; Hao Chen; Jin Xiang; Zhong-jun Xia; Yu-jing Zhang
• Keywords: International Prognostic Index; Regimen; B symptoms; Univariate analysis; Chemotherapy regimen; Progression-free survival; Performance status

Studies have found that lymphoma patients often exhibit abnormal lipid metabolism, and a decrease in serum high-density lipoprotein cholesterol (HDL-C) may occur during lymphomagenesis tumor growth. However, no literatures investigated the role of HDL-C with extranodal natural killer/T cell (ENKTL). In this study, we retrospectively reviewed level 107 newly diagnosed ENKTL received either l-asparaginase-based regimen or EPOCH as induction chemotherapy, evaluated its prognostic value. The mean was 1.10 mmol/L (range, 0.15–2.63), significantly lower elevated LDH beta 2-microglobulin (β2-MG) (p = 0.017 0.001, respectively) those who underwent disease progression died 0.031 0.007, respectively). univariate survival analysis, higher Eastern Cooperative Oncology Group performance status score (≥1), Ann Arbor stage III–IV, LDH, international index (IPI) (≥2 vs. 1 0), decreased (<40 mg/dL), β2-MG level, response after chemotherapy correlated poor progression-free (PFS) overall (OS) < 0.05). multivariate Cox regression model included IPI score, it were independent factors for OS 0.014 0.010, PFS 0.016 0.020, conclusion, to be valuable factor ENKTL, mechanism needs further investigated, which offer possibility therapeutic targets.