Overexpression of HER-2/neu protein attenuates the oxidative systemic profile in women diagnosed with breast cancer

• DOI: 10.1007/s13277-013-1391-x
• Publication Date: 2013-11-18T09:42:22Z
• Authors: Vanessa J. Victorino; Fernanda C. Campos; Ana C. S. A. Herrera; Andréa N. Colado ...; Alessandra L. Cec...; Carolina Panis; Rubens Cecchini
• Keywords: Malondialdehyde

About 20 % of breast cancer patients over-express the human epidermal growth factor receptor-2 (HER2), which is associated with enhanced tumor malignancy. The influence HER2 overexpression on oxidant/antioxidant parameters in humans remains unknown; therefore, we investigated oxidative profile women according to their status. Fifty-two controls and 52 (BC) were enrolled. BC subdivided into HER−, negative for overexpression, HER+, positive overexpression. Oxidative stress profilling was measured by malondialdehyde (MDA), free 8-isoprostane F2, protein carbonyl content, nitric oxide (NO), total radical antioxidant parameter (TRAP), superoxide dismutase (SOD), catalase activity, glutathione (GSH) levels. Total thiol content lipoperoxidation evaluated HCC1954 MCF-7. Cells overexpressing presented stress. Increased erythrocyte found patients, while plasma detected both HER− groups. Decreased MDA levels HER+ group, suggesting that may protects against lipoperoxidation. No alteration NO, content. TRAP decreased increased SOD prevented GSH These data help understand signaling enable development new strategies anti-HER2 therapy.