MMP-14 overexpression correlates with poor prognosis in non-small cell lung cancer

• DOI: 10.1007/s13277-014-2237-x
• Publication Date: 2014-07-02T07:58:19Z
• Authors: Yu-zhou Wang; Kun-peng Wu; Ai-bing Wu; Zhi-cheng Yang; Jin-mei Li; Yan-li Mo; Meng Xu; Bin Wu; Zhi-xiong Yang
• Keywords: Clinical Significance

Matrix metalloproteinase-14 (MMP-14) has been demonstrated to play an important role in tumor progression. The aim of this study was analyze the correlation between MMP-14 expression and clinicopathologic features its prognostic significance non-small cell lung cancer (NSCLC). Immunohistochemical staining for protein performed 104 patients with NSCLC. High levels were positively correlated status clinical stage (I-II vs. III-IV; P < 0.001), N classification (N0-N1 N2-N3; distant metastasis (no yes; = 0.014), differentiated degree (high low or undifferentiated; 0.001). higher had shorter survival time than expression. Multivariate analysis indicated that level independent indicator (P 0.001) In conclusion, is a potential unfavorable factor